Validated Target: Aminoacyl-tRNA Synthetases
Aminoacylation
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Aminoacyl-tRNA Synthetases (aaRS) constitute two universal families of enzymes which play a central role in protein biosynthesis. The nature of the biological function performed by aaRS makes the appearance of resistances due to punctual mutations in their catalytic cores highly improbable.
aaRS Inhibition is a proven mode of action for antiinfectives and validated in marketplace by the registration of Mupirocin (Bactroban ®).
Mupirocin (BACTROBAN ®)
- Family of 20 proteins
- Essential enzymes
- Universal distribution
- Easy to express and purify
- aaRS inhibitor Class proven in market: BACTROBAN ®
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Validation with Known Inhibitor
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Inhibition of the target leads to dose dependent reduction in cell flourescence. The assay is amenable for High Throughput Screening. |
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Our Technology 
The speed and focus of our targeted, proprietary platform dramatically reduces development time for anti-infectives and increases the probability of success